Agranulocytosis Successfully Treated with A.C.T.H

Chronic idiopathic agranulocytosis; report of a fatal case treated with corticotrophin (ACTH).

Severe Drug-Induced Agranulocytosis Successfully Treated with Recombinant Human Granulocyte Colony-Stimulating Factor

When elderly patients are prescribed many different medications, the risk for developing serious adverse events should be kept in mind. One of these adverse events is agranulocytosis, which, although rare, can be life-threatening if left untreated. The majority of agranulocytosis cases are caused by drugs, including antibiotics. Here, we report a case of severe agranulocytosis in a 96-year-old ...

Sjögren's syndrome treated with ACTH.

IN this paper we report observations on the treatment with ACTH of six female patients suffering from Sj6gren's syndrome. Each case was investigated on two occasions, an initial period of observation preceding the second admission for treatment. Five of the six patients underwent parotid biopsy, typical histological changes being seen in all. The methods used to assess improvement during therap...

Graves’ Disease Thyrotoxicosis and Propylthiouracil Related Agranulocytosis Successfully Treated with Therapeutic Plasma Exchange and G-CSF Followed by Total Thyroidectomy

Antithyroid drugs can be a rare cause of agranulocytosis (0.5% of treated patients). Suspension of these drugs is mandatory in these patients and may result in worsening hyperthyroidism. We report the case of a 27-year-old woman who is 3 months post-partum, breastfeeding, and suffering with Graves' disease hyperthyroidism treated first with methimazole and then with propylthiouracil due to a me...

Multicentric Reticulohistiocytosis Treated Successfully with Etanercept

Multicentric reticulohistiocytosis (MRH) is an uncommon systemic disease of unknown aetiology, which is characterized by the presence of papulonodular lesions, and is caused by the proliferation of histiocytes associated with arthritis. There are only just 200 cases described in the scientific literature. It can behave like a paraneoplasia and may be malignant in a quarter of the patients. We w...